All content © Simona Rapposelli

Designed by Massimiliano Runfola

MULTI TARGET

DIRECT LIGAND

STRATEGY

We have more than 15years experience in design and synthesis of small molecule able to simultaneously interact  with two or pathways.

Research

Our main research aim is to develop novel chemical compounds capable to interact simultaneously with two or more biological targets. The Multi-Target Directed Ligand Strategy (MTDL) has grown in the last decades as a valid alternative to classical mono-targeting therapy. In particular, our focus is the design and synthesis of molecules able to find a place in cancer and neurodegenerative disorders' therapy.

Main currently research topics are:

 

  :::  Design and synthesis of new molecules targeting chemoresistance in cancer therapy

  :::  Synthesis of new multitarget drugs through the combination of pharmacophoric moieties for the neurodegenerative diseases

  :::  Synthesis of small molecules to treat GBM.

Relevant Fundings 

For the complete list, check the Curriculum Vitae of Simona Rapposelli, here.

2019-2021  Public Funding

   PRIN2017 - Grant N° 2017XP72RF (National PI: Calderone V.)

Hydrogen Sulfide in the Vascular inflamm-Aging: role, therapeutic Opportunities and development of novel pharmacological tools for age-related cardiovascular diseases (SVAgO)

   Role of Partecipant

2019-2020  Public Funding

   Research project focused on the synthesis of new multitarget compounds for the treatment of neurodegenerative diseases (LIPID-AD)

   Funded by: University of Pisa

   Role of Principal Investigator

2015 to present Private Funding

   Research project focused on the synthesis of new multitarget compounds for the treatment of multifactorial pathologies

   Funded by: International Society for Drug Development (ISDD) (Milan, Italy)

   Role of Scientific Director

2014 - 2015 Private Funding

   Research project focused on design and synthesis of anticancer drugs

   Funded by: International Society for Drug Development (ISDD) (Milan, Italy)

   Role of Scientific Director

2013 - 2015 Private Funding   

   Reseach project in the field of anticancer drugs and regenerative medicine

   Funded by: International Society for Drug Development (ISDD) (Milan, Italy)

   Role of Scientific Director

2012 - 2015 Public Funding

   Future in Research - Grant N° RBFR10ZJQT ( National PI: Marinelli L)

   Mitochondrial medicinal chemistry against cell death-resistant cancers

   Role of Unit Principal Investigator

2011 - 2013 Public Funding

   Research Projects of National Interest (PRIN) - Grant N° 20097FJHPZ_003  ( National PI: Perrone R)

   Design and synthesis of new arylethylphenyl-derivatives as P-gp modulators for the treatment of neurodegenerative diseases and/or cerebral tumours

   Role of Unit Principal Investigator

2007 - 2008 Public Funding

   Fondazione Cassa di risparmio Lucca  (PI: Rapposelli S)

   Development of new molecules for the treatment of myocardial ischemia

   Role of Principal investigator